Christina Applegate has opened up about her daily battles with Multiple Sclerosis. Speaking on the Tuesday, November 5, episode of her “ MeSsy ” podcast, cohosted with Jamie-Lynn Sigler , who also suffers from the autoimmune disease, Applegate, 52, said she feels sharp pains “every single day.” “I lay in bed screaming,” Applegate said while detailing how the autoimmune disease manifests differently from person to person.

“Like, the sharp pains, the ache, the squeezing.” She noted that these symptoms affect her “every single day” of her life, adding that sometimes she isn’t able to pick up her phone or TV remote as a result of MS traveling into her hands. “I can’t open bottles now,” Applegate told Sigler, 43, and the pair’s guest, Rory Kandel , the founder of Rory’s Bakehouse in Napa.

According to Mayo Clinic , MS causes a breakdown “of the protective covering of nerves,” and can lead to numbness, weakness, difficulty when walking, impacted vision and further symptoms. Applegate’s candid health update comes after she revealed in April that she experienced an MS relapse this year. “I’m gonna be honest with you, I need to buy stock in Cottonelle because I haven’t taken a shower in three weeks,” Applegate said during the April 2 episode of “Messy.

” The actress continued at the time, “I can’t stand in my shower. There’s no f—ing way.” Applegate was diagnosed with MS in 2021, taking to social media at the time to share the.