Research from Harvard Pilgrim Health Care Institute indicates that bupropion users experience less weight gain compared to users of other common antidepressants like sertraline. This study, which used data from 183,118 adults and emulated a randomized trial, provides evidence that can help guide the choice of antidepressants based on potential weight gain impacts. A recent study indicates that bupropion is associated with less weight gain compared to other popular antidepressants, such as sertraline, providing valuable insight for patients and clinicians when choosing treatments.
New evidence comparing weight gain across eight different first-line antidepressants reveals that users of bupropion are 15-20% less likely to experience clinically significant weight gain compared to those taking sertraline, the most commonly prescribed medication. The findings are published July 2 in Annals of Internal Medicine . Antidepressants are among the most commonly prescribed medications in the U.
S., with 14% of U.S.
adults reporting using an antidepressant. Weight gain is a common side effect, which could affect patients’ long-term metabolic health and cause some to stop taking their prescribed treatment, leading to poor clinical outcomes. Although antidepressants overall are associated with weight gain, specific antidepressant medications may affect weight differently.
Study Methodology and Key Findings The new findings, led by investigators from the Harvard Pilgrim Health Care Institut.