Key players will be sidelined when the Champions League resumes Tuesday after a wave of injuries within a week of the new-look competition starting. Kylian Mbappé’s sore hamstring is likely to sideline him beyond Wednesday when he was due to return to France with defending champion Real Madrid to face Lille. Serious knee injuries mean Manchester City midfielder Rodri is out for the season and Barcelona goalkeeper Marc-André ter Stegen will miss at least most of it.

Inter Milan midfielder Nicolò Barella, who was a standout playing against Rodri on Sept. 18, will miss at least one Champions League game because of a thigh strain. The injuries to four players who were involved at the European Championship into the knockout phase have sharpened the debate about player workload in a calendar made more congested by the bigger Champions League.

The extended program is what influential clubs all-but forced UEFA to create and the 18 games this week, split between Tuesday and Wednesday, still leaves each of them with six more to play through January. There were two repeats of past finals in the first week of games that relaunched the Champions League in a single-standings format. Man City and Inter drew 0-0 and Liverpool won 3-1 at AC Milan.

The next rematch comes Wednesday when Aston Villa hosts Bayern Munich, a giant of the European Cup era that was shocked 1-0 in the 1982 final. Villa Park will host a first game in the competition since March 1983 when the English side’s ti.