( MENAFN - PR Newswire) SHANGHAI, Nov. 4, 2024 /PRNewswire/ -- BioCity Biopharma (BioCity) announced late-breaking results of the 2-SUCCEED clinical trial of SC0062, a selective endothelin receptor type A (ETA) antagonist, for the treatment of IgA Nephropathy (IgAN). These results were presented at the Oral Abstract Session of American Society of Nephrology (ASN) Kidney Week 2024 and published simultaneously in the Journal of the American Society of Nephrology (JASN), a leading kidney journal worldwide.
The 2-SUCCEED trial was designed as a multi-center, randomized, double-blind, placebo-controlled, two-cohort (IgAN and diabetic kidney disease [DKD]), Phase II study. The principal objective of the IgAN cohort was to evaluate the efficacy, safety, and optimal dose of SC0062 compared to placebo to determine SC0062's ability to reduce proteinuria in subjects at high risk of disease progression. The study allowed enrolment of subjects who were receiving sodium/glucose cotransporter 2 (SGLT2) inhibitors as a background therapy.
Overall, 131 patients were randomized in a 1:1:1:1 ratio to 24 weeks of treatment with either SC0062 doses of 5 mg, 10 mg, or 20 mg or placebo once daily. A similar evaluation of SC0062 in the 2-SUCCEED cohort of subjects with DKD is ongoing. Key 2-SUCCEED Study Results Presented at ASN: The detailed results of the clinical trial can be obtained from the manuscript entitled "The Selective Endothelin Receptor Antagonist SC0062 in IgA Nephropathy: A Randomize.