In a recent review published in Nutrients , researchers reviewed existing data on the role of the gut microbiome in Alzheimer’s disease (AD) pathogenesis. Study: Correlation between Alzheimer’s Disease and Gastrointestinal Tract Disorders . Image Credit: Joyisjoyful/Shutterstock.
com Introduction AD, the primary dementia cause worldwide, results in amyloid-β buildup, reduced synapses, and neurofibrillary tangles. Studies report links between the central nervous system (CNS) of the brain and the enteric nervous system (ENS) of the gastrointestinal tract. Microbial participation in AD pathogenesis might broaden the therapy options; however, the effects of gastrointestinal tract features on cognition are unclear.
Small sample sizes and lifestyle factors limit existing research. About the review In the present review, researchers discussed gut microbial alterations in AD patients. They searched the PubMed database in May 2024 for English articles published within the previous six years without study design or publication type restrictions.
They identified 2,259 records in PubMed and 12 by manual searching, screened 381, and assessed 113 full-text ones for eligibility. After excluding records that did not evaluate the research outcome, the team included 61 in the review. Microbiome-gut-brain (MGB) axis The microbiome-gut-brain axis connects peripheral intestinal function to the brain’s emotional and cognitive centers.
The sympathetic and parasympathetic nerves, the hypothala.