JetBlue Airways maintains a strong presence at New York LaGuardia Airport (LGA), with 172 weekly flights to various domestic destinations in September 2024, based on data from Cirium, an aviation analytics company. This high frequency demonstrates the airline's strategic commitment to serving one of the busiest airports in the United States, connecting travelers from a variety of significant destinations nationwide. Most popular route As JetBlue recently announced major expansion in New England, Boston Logan International Airport (BOS) is JetBlue's most frequent connection to LGA among all the routes.

With 47 weekly flights using Embraer E190 aircraft, this route connects two major East Coast cities. The aircraft type used here indicates that JetBlue focuses on running smaller jets to maximize capacity while maintaining frequent service, particularly during peak business travel hours. The amount of TrueBlue points required for a free flight depends on various factors.

The sunshine state Fort Lauderdale-Hollywood International Airport ( FLL ) is another major destination for JetBlue's LaGuardia operations. With 31 weekly flights, mainly on the Airbus A320, this route serves leisure and business visitors. The use of larger aircraft, such as the A320, with 161 to 162 seats each trip, shows the great demand for this route, which connects New York and South Florida's major locations.

Another key route is Orlando International Airport (MCO), which has 24 weekly flights operated by .