Adipo Therapeutics LLC, a late-stage, preclinical biopharmaceutical company developing a potential treatment for obesity and related metabolic disorders, presented data from two studies at the annual meeting of The Obesity Society in San Antonio. The studies were designed to evaluate the impact of Adipo's active ingredient ADPO-002 on key browning markers for mitochondrial biogenesis, mitochondrial activation and adipocyte browning in human fat cells and fat tissues. The increases in PGC1⍺, PRDM16 and Uncoupling Protein 1 (UCP1) in these studies support ADPO-002's mechanism of action for mitochondrial biogenesis, activation and browning of human white adipose tissue, and the potential for the translation of Adipo's treatment to humans.
Why brown adipose tissue matters Obesity is a significant public health crisis. According to the National Institutes of Health, by 2030 nearly half of U.S.
adults will be obese. People who are overweight or are affected by obesity are at increased risk for many serious diseases and health conditions including Type 2 diabetes, fatty liver and gallbladder diseases, high blood pressure, dyslipidemia, cardiovascular diseases, sleep apnea, breathing disorders, osteoarthritis, mental illness, and some cancers. Excess energy-storing white adipose tissue is associated with obesity, Type 2 diabetes mellitus and cardiovascular disease whereas energy-burning brown adipose tissue plays a beneficial role in overall metabolic health.
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