Type 2 diabetes and prediabetes are associated with accelerated brain aging, according to a new study from Karolinska Institutet in Sweden published in the journal Diabetes Care . The good news is that this may be counteracted by a healthy lifestyle. Type 2 diabetes is a known risk factor for dementia , but it is unclear how diabetes and its early stages, known as prediabetes, affect brain aging in people without dementia.
Now, a comprehensive brain imaging study shows that both diabetes and prediabetes can be linked to accelerated brain aging. The study included more than 31,000 people between 40 and 70 years of age from the UK Biobank who had undergone a brain MRI scan ( magnetic resonance imaging ). The researchers used a machine learning approach to estimate brain age in relation to the person's chronological age.
Prediabetes and diabetes were associated with brains that were 0.5 and 2.3 years older than chronological age, respectively.
In people with poorly controlled diabetes, the brain appeared more than four years older than chronological age. The researchers also noted that the gap between brain age and chronological age increased slightly over time in people with diabetes. These associations were attenuated among people with high physical activity who abstained from smoking and heavy alcohol consumption.
"Having an older-appearing brain for one's chronological age can indicate deviation from the normal aging process and may constitute an early warning sign for demen.